Gastric metastasis of a renal cell carcinoma presenting as a polypoid mass.

Renal cell carcinomas (RCCs) account for approximately 3% of adult malignancies. More than 50% of RCCs are detected incidentally, and in approximately one-third of patients, RCCs have metastasized at the time of initial diagnosis [1]. The sites of metastasis includethe lungs (75%), soft tissues (36%), bones (20%), liver (18%), skin (8%), and central nervous system (8%) [2]. Gastric metastases of RCC are extremely rare, with only 23 cases reported in the literature [3]. We describe here a case of metastatic RCC presenting as a polypoid mass 7cm in diameter. A 59-year-old man was admitted to our hospital with weight loss and melena. He had undergone a right radical nephrectomy for a diagnosis of RCC 4 years earlier. On endoscopic examination, an ulcerated polyp 7cm in diameter was noted in the corpus of the stomach. The patient underwent a partial gastrectomy, and a gastric adenocarcinoma was diagnosed. In the resected specimen, the tumor, which measured 7cm, was a polypoid mass with an ulcerative growth pattern and some hemorrhagic areas. Based on the morphologic (●" Fig.1, ●" Fig.2) and immunohistochemical (●" Fig.3, ●" Fig.4) features of the lesion, we diagnosed metastatic clear cell RCC. The stomach is an unusual site of metastasis, even in autopsy series. Gastric metastases are most often from carcinomas of the lung and breast and from malignant melanomas [4]. Gastric metastases of RCC are very rare. According to the literature, most gastric metastases of RCCs occur in male patients. The mean time to metastasis is nearly 7 years (0–20 years). Gastric metastases are more common in the body of the stomach and tend to be a solitary mass or an ulcer resembling a primary gastric tumor [5]. Patients with RCC who undergo nephrectomy should be carefully followed upwith imaging methods. The early treatment of RCC metastases to distant organs can be important for patient survival. Thediagnosis of metastatic RCC should be considered if a patient has a history of RCC with clear cell morphology of the tumor cells.